We thus examined whether TRIM69 isoform B might similarly inhibit the anti-VSIV activity of isoform A. When TRIM69 (isoform A) was constitutively expressed, it conferred potent protection from VSIV-GFP infection (Fig. 3E), and this protection was further enhanced by the presence of inducible myc-tagged TRIM69 (Fig. 3E). Here, MYC is linked to infection.