AKT1 and nasopharyngeal carcinoma: Cripto-1 also interacts with TGF-β1 and activin A and B to interfere and weaken their signaling in a variety of cell lines, acts as Glycosyl Phosphatidyl Inositol (GPI) ligand that activates MAPK and PI3K/protein kinase B (Akt) signaling pathways to regulate cell proliferation, migration and survival.24, 25, 26, 27 Therefore, it is reasonable to suggest that there is a correlation between LMP1 and Cripto-1 in human NPC.