In this study we evaluated the effect of elevated Ang II concentration on SGLT2 expression and the effect of this increased SGLT2 expression on BP and kidney damage by comparing prevention of the Ang II-induced kidney damage by either AT1 receptor blockade (Losartan), SGLT2 inhibition (Empagliflozin) monotherapy or by the combination of both treatments. The gene discussed is SLC5A2; the disease is Nephropathy.