UCP3 and metabolic dysfunction-associated steatotic liver disease: Furthermore, a non-coding variant in the promoter (-55C>T, rs1800849) of UCP3, encoding for the uncoupling protein 3, a mitochondrial transporter that increases the proton leak of the inner membrane of mitochondria and uncouples the oxidative phosphorylation, has been shown to be involved in NAFLD susceptibility [48].