PNPLA3 and metabolic dysfunction-associated steatotic liver disease: For example, in experimental models of NAFLD/NASH in mice wild-type or knock-in for the Pnpla3 I148M variant, Pnpla3 silencing by means of antisense oligonucleotides (ASO) was associated with reduced liver inflammation and fibrosis, which was more marked in mice homozygous for the 148M/M mutation [87].