APEX1 and Cirrhosis: Multivariate analysis with other clinicopathological values including age, sex, HBV infection, cirrhosis, histologic grading, and pathologic TNM staging showed that cytoplasmic APEX1 expression in HCC and CC cells is also a predictor of a shorter DFS period (p = 0.009 and p = 0.011, respectively) (Table 5 and Table 6).