SNAI1 and ovarian carcinoma: For example, in ovarian carcinoma cell lines, SRg3 was the only epimer that inhibited migration and invasion via blocking hypoxia-induced epithelial-mesenchymal transition (EMT), the degradation of hypoxia-inducible factor-1α (HIF-1α) and the transcriptional repression of Snail and hence E-cadherin [49].