To confirm whether the suppression of liver fibrosis by Melon GliSODin® is regulated at the level of gene expression, the expression of collagen type 1 alpha (col1a1), collagen type 3 alpha 1 (col3a1) (fibrosis markers) and transforming growth factor beta (TGF-β) (an upstream regulator of col1a1 and col3a1) were determined [21]. The gene discussed is COL1A1; the disease is Hepatic fibrosis.