Given that epithelial cells are innately inefficient at centrosome clustering [62], such PIK3CA-induced epithelial-to-mesenchymal transition and altered cortical tension may enable these cells to efficiently cluster supernumerary centrosomes [62] and divide in the wake of misaligned chromosomes, pre-disposing them to CIN. The gene discussed is PIK3CA; the disease is cervical squamous intraepithelial neoplasia.