PIK3CD and diffuse large B-cell lymphoma: In haematological malignancies, PIK3CA mutation or amplification is extremely rare (<0.1% in lymphoid and myeloid malignancies; cBioportal, accessed June 2019), with a slightly higher frequency of these events in PIK3CD (1% in lymphoid and myeloid malignancies; cBioportal, accessed June 2019), which is almost exclusively constituted by mutations in PIK3CD in diffuse large B-cell lymphoma.