TP53 and cancer: Numerous researches have been reported to elucidate that the MeJA can induce autophagy in cancer, for example, MeJA induces p53-dependent apoptotic and p53-independent non-apoptotic cell death in cancer [23,24,25], MeJA induces apoptosis via the ROS pathway, while simultaneously inducing pro-apoptotic autophagy in human non-small cell lung cancer [23].