Similarly, both in rats with increased IOP and in rats with STZ-induced diabetic retinopathy, retinal ganglion cells were protected from apoptotic cell death by the administration of an ACE2 activator [45,46], while ACE2 gene delivery to diabetic mice or rats reduced oxidative stress, inflammation, vascular leakage, and the formation of acellular capillaries [47]. This evidence concerns the gene ACE2 and diabetic retinopathy.