MMP2 and hepatocellular carcinoma: ApoA-I also induced downregulation of vascular growth factor (VEGF) and matrix metalloproteinases 2 and 9 (MMP2, MMP9) genes, suggesting that ApoA-I may decrease the angiogenetic potential and the ability of HCC cells to remodel extracellular matrix, inhibiting in this way their metastatic potential [100].