In addition, by using a murine model of atherosclerosis, it was shown that myeloid Abca1/g1 deficiency enhanced caspase-1 activation in monocytes, macrophages, and neutrophils, resulting in enhanced atherogenesis that was suppressed by Nlrp3 or Caspase-1/11 deficiency [56,57]. This evidence concerns the gene ABCA1 and atherosclerosis.