TLR4 and Sepsis: Clearance of LPS through binding of HDL-LPS to SR-BI results in lower activation of the Toll-like receptor 4 (TLR4), the corresponding pathogen-associated molecular pattern (PAMP) recognition receptor, and in decreased production of tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6) by the proinflammatory cells that mediate sepsis pathology [29,35,36].