Recently, it was observed that, in hypoxic conditions, ovarian cancer cells, through the action of the oncogenic transcription factor Signal Transducer and Activator of Transcription 3 (STAT3,) upregulate RAB27 (a RAB protein controlling late endosome docking with the plasma membrane) and downregulate RAB7 [121]. The gene discussed is STAT3; the disease is ovarian cancer.