CHEK2 and neoplasm: Next-generation sequencing of HGSOC tumours revealed that, independent of BRCA1/2, mutations in HR effectors, such as partner and localizer of BRCA2 (PALB2), RAD51, ATM, BRCA1-interacting protein 1 (BRIP1), BRCA1-associated RING domain protein 1 (BARD1), and checkpoint kinase 2 (CHEK2) occurs in up to 20% of HGSOC [12].