Strikingly and similarly, we also found that direct p53 reactivation (PRIMA-1Met, APR-246) brakes resistance and synergizes with MEK inhibition to induce massive apoptosis in NRAS (Neuroblastoma rat sarcoma (RAS) viral oncogene homolog) -mutant melanoma cells with wild-type or mutant p53 [43]. Here, TP53 is linked to melanoma.