TP53 and neoplasm: RT alone slightly decreased tumor growth compared to that which was non-irradiated (left panel, untreated control, or CTR) but importantly, the combination of BRAF inhibition plus RT or RT plus p53 activation showed a synergistic effect on tumor growth inhibition (CI = 0.2 and 0.68, respectively) in comparison with non-irradiated tumors (left panel).