In relation to this angiogenic property, it was reported that when CXCL1 produced by melanoma cells binds to CXCR1 or CXCR2 receptors expressed in endothelial cells, it can induce the recruitment of these cells to the tumor microenvironment, leading to the formation of new vessels [23,24]. This evidence concerns the gene CXCR1 and melanoma.