IL6 and melanoma: In relation to the context of IL-6 and melanoma cancer, while increased expression of this cytokine in the melanoma microenvironment has been shown to favor the occurrence of tumor cachexia [28] and metastasis [29,30], it was reported that omega-3 and its metabolites can decrease tumor growth of both human non-melanoma skin carcinoma cells [31] and melanoma cells [32] through the reduction of pro-inflammatory cytokines levels, such as IL-6, in the tumor microenvironment.