Based on the information cited above, we evaluated how the treatment with the mixture of omega-3 and omega-6 (1:1 ratio) alters the favorable conditions to the melanoma growth through of analysis of the inflammatory mediator (LTB4, LTB5, PGE2, and PGE3) and cytokines (IL-6, IL-10, and CXCL1) levels in the melanoma microenvironment. The gene discussed is CXCL1; the disease is melanoma.