Furthermore, culture of colon cancer cell line, COLO-205, with folic acid (vitamin B9) inhibited cell proliferation via G0/G1 cell cycle arrest and through activation of c-SRC mediated pathway and increased levels of cyclin-dependent kinase inhibitor 1A, 1B and tumor protein p53 [51]. Here, CDKN1A is linked to malignant colon neoplasm.