IGHE and allergic disease: In contrast, patients with a physician-diagnosed sesame allergy who did not report a history of convincing reaction symptoms were more frequently diagnosed via serum IgE testing (52.8%; 95% CI, 36.4%-68.7%), followed by skin prick tests (43.1%; 95% CI, 28.4%-59.2%) and oral food challenge (7.8%; 95% CI, 3.4%-16.9%).