IGHE and allergic disease: The fact that self-reported or perceived food allergy is associated with psychosocial impairment and decreased quality of life owing to the challenges of allergen avoidance underlines the importance of confirmatory allergy testing irrespective of test outcome.25,26,27,28,29 In addition, the relatively low rates of physician diagnosis observed among individuals with convincing IgE-mediated sesame allergy would seem to indicate potential missed opportunities for patient counseling and education, as well as prescription of potentially life-saving medication.