The rising prevalence of obesity among older adults91,92 needs greater attention because this condition, particularly abdominal obesity, may increase the risk of frailty through the association with proinflammatory processes, insulin resistance, fat infiltration of skeletal muscles, and hormonal alterations.93,94 Many other sociodemographic, physical, biological, lifestyle (eg, smoking), and psychological factors may equally contribute to the development of frailty and thus require tailored solutions in different settings.95,96,97,98. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.