CTLA4 and neoplasm: Similarly, Du et al. showed that intratumoral treatment of subcutaneous lung cancer (CMT-64)-bearing mice with replication competent oncolytic adenovirus encoding for anti-CTLA-4 antibody resulted in decreased tumor burden, but data on toxicities were not available and no comparison with adenovirus plus systemic anti-CTLA-4 treatment was presented [108].