In a previous study, no association was found between TGF‐β1 rs1800470 polymorphism and leukemia.16 In contrast, Nursal et al showed that variants of TNF‐α 238G>A rs361525, IL‐10 (−1082G>A rs1800896, −819C>T rs1800871, −592C>A rs1800872), and TGF‐β1 (codon 25) genes may have a significant association with AML etiopathogenesis.17 However, no association was observed between TNF‐α −308G>A, IL‐10 (−592T>G, −819T>C, −1082T>C), IFN‐γ +874T>A and TGF‐β1 (codons 10 and 25) polymorphisms and the risk of CML.13 This evidence concerns the gene TNF and leukemia.