The objectives of this study were to evaluate: (a) the multivariate effect of eight SNPs [TNF‐α 238G>A (rs361525); 376G>A (rs1800750); 308G>A (rs1800629)], IL‐10 −1082T>C (rs1800896); −592T>G (rs1800872), IL‐6 174C>G (rs1800795), TGF‐β1 869C>T (rs1800470), IFN‐γ +874T>A (rs2430561)] on AML risk; (b) the multivariate effect of the eight SNPs on OS in AML patients; (c) the association between studied polymorphisms and clinical prognostic factors in AML patients. This evidence concerns the gene IL6 and acute myeloid leukemia.