MAPT and stroke disorder: Repeated subconcussive head impacts or a mix of impacts and blast injuries can induce CTE.29,31 In 2016, the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) issued a consensus paper that defined the pathology of CTE as an irregular pattern of accumulation of hyperphosphorylated tau (p-tau) protein in neurons and astroglia about the small vessels located within the cortical sulci (McKee et al.31,33,34).