Analysis of the p300 level (Fig. 6) was also performed for HTC116 tumor cells, for which both models of senescence (following 7,5 and 10 μM curcumin or 100 nM doxorubicin treatment) have already been described (Mosieniak et al. 2012; Sliwinska et al. 2009; Mosieniak et al. 2016). This evidence concerns the gene EP300 and neoplasm.