JAK1 and cancer: No germline single-nucleotide variants with established cancer relevance were detected.10 Although no therapy was available to target the EWSR1-ATF1 fusion protein directly, the POG RNA-Seq–derived gene expression analysis identified high expression of downstream genes IL6 and JAK1. The finding of the JAK1 overexpression was corroborated by comparative RNA-Seq analysis at the University of California Santa Cruz.