SPP1 and Thoracic scoliosis: Yadav and colleagues43 investigated the interplay between PHOSPHO1 and OPN through the generation of Phospho1–/–; Spp1–/– mice and found a partial rescue of the Phospho1–/– phenotype, with animals at 1 month and 3 months of age exhibiting a reduction in the typical hyperosteoidosis and thoracic scoliosis that characterizes the single knockout animal.