TGFB1 and osteogenesis imperfecta: TGF‐β is an important signaling molecule in bone homeostasis and a coupling factor between bone resorption and bone formation.58 Mouse models of increased TGF‐β signaling exhibit high bone turnover, low bone mass, and increased osteocyte density;59 whereas downregulation of TGF‐β signaling results in decreased bone resorption, high bone mass, and decreased osteocyte density.60 Excessive TGF‐β signaling has been recently identified as a seminal pathogenetic mechanism in OI.23 Our transcriptome analysis suggests for the first time that osteocytes are also targets of increased TGF‐β signaling.