We showed that the osteocyte RANKL deletion in oim/oim mice completely rescued the loss of cancellous bone mass in these mice, indicating that osteocytes significantly contribute to the low bone mass observed in OI.50 In the latter approach and the subject of this study, we set out to compare the transcriptome of osteocytes from control mice with that of osteocytes derived from two mouse models of OI, the CrtapKO and the oim/oim mouse. The gene discussed is TNFSF11; the disease is osteogenesis imperfecta.