Compared with women with p53− tumors, those with p53+ tumors were generally younger (P-value = 0.01) and had higher frequencies of aggressive tumor features including poorly differentiated (P-value = 1.06 × 10−26), large size (P-value = 0.002), more proliferative (higher frequency of KI67+; P-value = 1.96 × 10−35), CK5/6+ (P-value = 4.31 × 10−11), EGFR+ (P-value = 3.55 × 10−20), and aggressive molecular subtypes (B-like/HER2−, B-like/HER2+, HER2-enriched and TN; P-value = 7.21 × 10−30) (Table 1). The gene discussed is ERBB2; the disease is neoplasm.