As such, LCN-2 is predominantly an osteoblast and adipocyte derived 25 kDa secreted glycoprotein which acts as a lipid chaperone positioning itself as a key pro-inflammatory link between obesity and associated metabolic disorders and vascular disease (Kjeldsen et al., 1993; Wang, 2012). The gene discussed is LCN2; the disease is obesity due to melanocortin 4 receptor deficiency.