A number of epidemiological studies in humans have reported associations between increased circulating FGF23 concentrations and vascular dysfunction (Mirza et al., 2009a), vascular calcification (Roos et al., 2008; Desjardins et al., 2012) and increased risk of cardiovascular disease (Dalal et al., 2011). The gene discussed is FGF23; the disease is cardiovascular disorder.