Then, we tested DKK2 blockade in a mouse lung cancer model of carrying an activating Kras mutation and loss of Apc. Treatment of these mice with anti-DKK2 antibody significantly reduced tumor number and tumor size (Fig. 7a–c), and enhanced activation of NK cells in both of tumor draining lymphoid node and tumor tissues (Fig. 7f, g). This evidence concerns the gene KRAS and lung cancer.