In hepatocellular carcinoma, we previously demonstrated that NOR1 increases the expression of growth factor receptor-bound protein 2 (Grb2) mRNA in the human hepatocellular carcinoma cells, and NOR1 enhanced monofunctional alkylating agent 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)-induced cell killing in HCC cells, but this effect was reversed by stable transfection of Grb2 small hairpin RNA24. The gene discussed is OSCP1; the disease is hepatocellular carcinoma.