The frequent neural crest embryonal origin of both pheochromocytoma and neuroblastoma with the common loss of the locus 1p35-36 in the last tumors, a section where SDHB gene is located, suggested that genetic alterations in SDHB might be related to the progression or advanced neuroblastoma tumors12. This evidence concerns the gene SDHB and hereditary pheochromocytoma-paraganglioma.