ADAR and Aicardi-Goutieres syndrome: AGS can be caused by mutations in the three prime repair exonuclease 1 (TREX1) [35], SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) [36], adenosine deaminase RNA specific (ADAR) [37], interferon induced with helicase C domain 1 (IFIH1) [38] genes, or subunits of the RNase H2 complex [39].