ERVW-1 and amyotrophic lateral sclerosis: Two studies argue that HERVK transcripts show no difference between ALS patients and unaffected individuals [113, 118, 119], one found no detectable HERVK-Env protein in cortex and spinal cord by Western analysis [118, 119], while the third found no evidence for general retrotransposon elevation after reanalyzing published datasets [113, 118].