In this study, the relationship between the most representative apoptosis markers (cleaved caspase-3 and cleaved caspase-9 [28]) and Malat1 was detected, which was in agreement with the increased expression of cleaved caspase-3, while the expression of cleaved caspase-9, another caspase protease, indicated no significant difference in the CRC cell lines in comparison with the control. This evidence concerns the gene MALAT1 and colorectal carcinoma.