SMAD3 and allergic disease: These findings agree with the possible genetic effect in of allergy among family members9 and with the recent genetic researches which identified many genetic loci at different Interleukin (IL) “IL1RL1IL18R1, HLA-DQ, IL33, SMAD3, ORMDL3 GSDMB & IL2RB” and these are found to be related to allergic disorders.15