Allergy is a widespread global public health problem.1 It has continuously escalating rates, and it can lead to serious complications.1,2 The etiology of allergy is due to interactions between both environmental factors, with the permissive genetic factors.3 Allergy is a hypersensitivity reaction in which the immune mechanism responds (by IgE antibody) to the environmental materials (allergen) that are normally considered harmless.4 Here, IGHE is linked to allergic disease.