PON1 decreases lipid peroxide accumulation in LDL due to its antioxidant ability against hydroperoxides thus reduce LDL and phospholipid oxidation, Thus, PON1 may be involved against atherosclerosis protection.1 Diabetes mellitus (DM), is a life-threatening chronic disease associated with about 10% death episodes in adults.2 DM is leading risk factor for development of coronary heart diseases and mortality if not properly managed.3 The gene discussed is PON1; the disease is coronary artery disorder.