In recent meta-analysis study that involved 35 studies worldwide, PON1 has been shown to decrease in DM and to be associated with the risk of diabetic macroangiopathy and microangiopathy.4 In addition, in another meta-analysis, PON1 polymorphisms have been shown to play an important role in the susceptibility of diabetic macroangiopathy and microangiopathy.5 This evidence concerns the gene PON1 and diabetes mellitus.