TPO and Jeune syndrome: The positivity for serum anti-TPO antibodies reported in this study was consistent with other studies.9-14 The lower percentage of positive Anti TPO than anti TG may be because that the anti TPO was more specific than Anti TGA.15 For this reason the Anti-TPO assayed by monoclonal anti body assisted RIA appears to be a more sensitive and specific marker for ATD than the conventional other tests.15 This also noted by Berg et al. in their study, and this was explained in that; the Anti TPO is associated with more elevation of TSH than ATG.16