PRNP and infection: To demonstrate how the unrestrained nature of bank vole PrP can be used to develop a more ubiquitous infection platform, we tested two cervid prion isolates, white-tailed deer (WTD) and mule deer (MD) CWD prions, for prion infection in BVPrP expressing CAD5 (CAD5_BV) and MEF (MEF_BV) cells.