HHIP and Glucose intolerance: Despite the fact that female sex has been reported to be protective against HFD-induced metabolic disorders23–25, both sexes of HFD-Hhip+/+ mice displayed a similar ipGTT pattern in our study, and the impaired glucose intolerance was improved only in male HFD-Hhip+/− mice, but not in female HFD-Hhip+/− mice.