Interesting, the top 4 enriched pathways were significantly relevant to Immune reaction, including cytokine-cytokine receptor interaction (P = 4.61 × 10−13), rheumatoid arthritis (P = 1.90 × 10−6), chemokine signaling pathway (P = 1.01 × 10−5) and TNF signaling pathway (P = 2.79 × 10−4). Here, TNF is linked to rheumatoid arthritis.