PDK1 and amyloidosis: In any case, inhibiting PDK1 counteracts the toxicity of both prion and transmitted Aβ seeds as BX912 infusion in prion-infected APP23 mice not only reduces the load of PrPSc, but also the brain deposition of Aβ, which thus reinforces the critical role of PDK1 in amyloid-based neurodegenerative diseases23,24,57,58.