CD4 and neoplasm: Indeed, while previous studies demonstrated that highly toxic UVC doses (100J) can trigger ICD33, and that CD4+ T cells subjected to 8-MOP plus UVA irradiation drive C-X-C motif chemokine ligand 8 (CXCL8) secretion from monocytes34 (knowing that CXCL8 is involved in the perception of cell death as immunogenic)35, the ability of ECP-treated cancer cells to initiate adaptive, tumor-specific immunity remained unexplored.