We revealed that PVT1 promotes the recruitment of H3K27me3 in the FOXA1 promoter region by recruiting EZH2 and thus inhibits the expression of FOXA1 to promote the apoptosis and damage of podocytes in DN, suggesting that downregulation of PVT1 might be a potential target in the treatment of DN. The gene discussed is PVT1; the disease is liver dysplastic nodule.