Periodic acid-Schiff staining showed that the mesangial matrix was widely proliferated, the mesangial region was broadened, the basement membrane was thickened, and the glomerulosclerosis was slightly hardened in the sh-NC and sh-PVT1 + sh-FOXA groups; the degree of glomerulosclerosis and renal tubule atrophy were significantly relieved in the sh-PVT1 and GSK126 groups (all p < 0.05) (Fig. 5c). The gene discussed is PVT1; the disease is glomerulosclerosis.