Compared with those in the sh-NC group, the number of podocytes was elevated and glomerulosclerosis was reduced in the sh-PVT1 group and the GSK126 group (both p < 0.05), but there were no significant differences between those of the sh-NC and sh-PVT1 + sh-FOXA1 groups (p > 0.05). The gene discussed is PVT1; the disease is glomerulosclerosis.