On the other hand, decreased expression of XPO5 had been found in liver and bladder cancers [17,53].The aberrant expression of XPO5 significantly suppressed cell proliferation, colony formation, growth in soft agar and tumorigenicity in nude mice collectively demonstrating that XPO5 functions as a tumor suppressor in the progression of HCC [17]. This evidence concerns the gene XPO5 and urinary bladder carcinoma.