For instance, transgenic FGF-2 overexpression results in dwarfism in mice (Coffin et al., 1995), and activating FGFR3 mutations lead to achondroplasia and shortened long bones with disorganized chondrocyte columns in growth plate (Chen et al., 1999; Lee et al., 2017). The gene discussed is FGF2; the disease is Severe short stature.