Therefore, although the transcriptomic analysis suggested that scrib mutant tumors have extensive changes besides the MAPK pathway, including several metabolic pathways and other signaling pathways such as the Notch and JAK/STAT pathways, we first focused on examining whether JNK and ERK signaling activities change over time and whether these changes have functional implications regarding scrib tumor growth. This evidence concerns the gene MAPK8 and neoplasm.