SMYD2 and triple-A syndrome: More importantly, Toghill et al. assessed global DNA methylation in peripheral blood mononuclear cell DNA from 92 AAA cases and 93 controls; their data showed that four CpGs (NC_000001.11: 214280412, 214280441, 214280507, and 214280600) were hypomethylated in the SMYD2 promoter upstream of the transcriptional start site in AAA patients compared to controls [61].