Higher SMYD2 mRNA expression level is observed in renal cell tumors than in normal renal tissues, and SMYD2 mRNA levels discriminated renal cell tumors from normal renal tissue with 100% specificity and 82.1% sensitivity and distinguished chromophobe subtype renal cell carcinoma (chRCC) from oncocytoma, with 73.3% specificity and 71.0% sensitivity [75]. The gene discussed is SMYD2; the disease is chromophobe renal cell carcinoma.