In contrast, corticosterone was able to protect against the reduction in trabecular number in this model of inflammatory polyarthritis (Tb.N: TNF-tg/vehicle, 0.0004 1/μm ± 0.00002 vs TNF-tg/corticosterone, 0.00083 1/μm ± 0.00002, P < 0.0001) (Fig. 2d). Here, TNF is linked to polyarticular arthritis.