An analysis of the correlation between CRC-related gene set enrichment and RUNX1 expression showed statistically significant (NES = 1.54, p = 0.006) results in TCGA database, and Gene Set Enrichment Analysis (GSEA) (http://software.broadinstitute.org/gsea/index.jsp) suggested a significant correlation between RUNX1 expression and these genes (Fig. 1d). Here, RUNX1 is linked to colorectal carcinoma.