A study involving leukaemia reported that Wnt/β-catenin signalling increases the expression of the ETO and RUNX1 genes in human haematopoietic progenitors [21], and the distal P1-RUNX1 promoter is a direct transcriptional target of Wnt/β-catenin signalling [22]. This evidence concerns the gene RUNX1 and leukemia.