Recently, HCC CSCs were identified based on the expression of various cell surface markers, including CD90 [10], CD13 [11], CD133 [12], epithelial cell adhesion molecular (EpCAM) [13], CD24 [14], OV6 [15], and Intercellular adhesion molecule 1 (ICAM1) [16]. Here, EPCAM is linked to hepatocellular carcinoma.