Regarding basal transcriptional differences between HC and AD LCLs, we observed that AD lymphoblasts exhibited general upregulation of CASP1 and SOD2 and downregulation of CCS. Consistently, CASP1 is activated in AD brains and overexpressed in monocytes from AD patients, and it is in fact considered a therapeutic target against age-dependent cognitive deficits and AD [92,93]. This evidence concerns the gene CCS and Alzheimer disease.