NFE2L2 and Alzheimer disease: Interestingly, we observed a general upregulation of the following genes caused by RV: CAT, CCS, GSTZ1, NFE2L2, SIRT1, SIRT3, SOD2, and TXNIP. Treatment with the highest concentration of RV (50 μM) consistently upregulated CAT, CCS, GSTZ1, NFE2L2, SIRT1, SIRT3, SOD2, TXNIP, and VPS13C in both AD and HC LCLs (there was a global RV effect for all these genes).