Treatment with HSP90 inhibitors of lung adenocarcinoma cell lines, as expected, showed remarkable changes in the homeostasis of HSPs, leading to deregulation of HSP90, HSP70, HSP60, HSC71, HSP70 protein 6 (HSPA6), and mitochondrial HSP70 (mitHSP70). This evidence concerns the gene HSPA8 and lung adenocarcinoma.