Concretely, the I subunit of the eIF3 complex (eIF3i) was found to be overexpressed in different tumor types including colon adenocarcinoma and adenoma, head and neck squamous cell carcinomas, hepatocellular carcinoma, breast cancer, cervical cancer and metastatic melanoma [77,78,79,80,81]. Here, EIF3A is linked to metastatic melanoma.